Chase Suno and his two best friends, Bren and Jinja learn that Jeredy Suno (Chase's father/Scientist - Worked for S.T.O.R.M.) is missing. Jon Ace and S.T.O.R.M. (Strategic Tactical Operatives for Recovery of Monsuno) join Chase at the lab, but it is soon revealed that they are after the fully loaded Core that Jeredy left behind for his son. Chase learns how to use his Monsuno in which he named it , Lock, which came from an old saying his father, Jeredy Suno stated.

Chase discovers that his father had created a Monsuno called Quickforce, who is being held captive and experimented on by S.T.O.R.M. and is unpredictable. (Quickforce may reject someone's control and possibly kill him/her.) Chase leads a brave infiltration of the S.T.O.R.M. facility in order to save Quickforce. Chase leads the guards away and fights Ace while Bren and Jinja find Quickforce. After playing rock, paper, scissors to see who gets to be Quickforce's master, Bren rescues Quickforce and is now his "master" like Chase is with his Monsuno, Lock. Together, they take care of Trey's Monsuno, Riccoshot.

The trio heads to Axistown where they meet a mysterious woman who sends them to an underground fight club; Jinja obtains her own Monsuno she calls Charger.

The leader of a mercenary clan lures Chase to an abandoned facility for a duel of Monsunos.

After being captured by the evil Bookman, Chase, Bren, and Jinja must team up with a monk named Beyal in order to escape.

S.T.O.R.M. sets up a blockade to keep anyone from leaving Mandala; Chase becomes convinced that he and his friends must attack S.T.O.R.M..

The Core-Tech Team Monsuno duel with Dax; Dr. Klipse joins forces with Chase to find Jeredy's whereabouts.

While following Dax, The Core-Tech Team happen to catch sight of Jeredy Suno when they're suddenly attacked by Dark Spin mercenaries. Before being separated once more, Jeredy gives his son a new Monsuno named Evo.

Dax betrays The Core-Tech Team to Charlemagne for Monsuno Essence, but it turns out to be a combined strategy of both him and Chase.

Under constant robot drone attack, Jon Ace warns Chase he has a spy in his midst and invites him to join S.T.O.R.M., which he accepts. Without him the rest of The Core-Tech Team start arguing which results in a 2 on 2 battle amongst themselves. While on his way to S.T.O.R.M., Chase changes his mind and wants to go back to his team, but they first have to escape the S.T.O.R.M. attack planes. Meanwhile, Dark Spin attacks the rest of The Core-Tech Team.

While stumbling onto what appears to be an ancient Monsuno temple in the jungle with Jon Ace, The Core-Tech Team team are attacked, captured, and their cores stolen by the crazy Dom Pyro, an agent of the Eklipse Organization.

Jon Ace takes The Core-Tech Team to what used to be a Monsuno Essence mine run by Jeredy Suno, but is now an Eklipse Organization research faculty. While The Core-Tech Team seeks information on Jeredy, Jon Ace seeks to destroy the Monsuno Essence because he believes it is too dangerous.

Chase, Bren, Jinja, and Beyal have a vision of the future in which Lock goes rouge and cause widespread destruction. While contemplating this vision Chase is attacked by a S.T.O.R.M. soldier. In fear of what Lock might do, Chase orders Lock away. In the desert, Lock happens upon a Monsuno core buried in the ground and absorbs its essence. In this confused state, a former S.T.O.R.M. agent named Jack uses Lock for his own purposes.

Chase heads to a special library to obtain an ancient book to fix his bond with Lock. When they get there and get the book, The Dawnmaster steals it. Then Chase and the others chase after him and Chase eventually gets the book as he is captured. The bookman tries to make Lock his Monsuno, but it doesn't work. The Dawnmaster battles The Bookman's Monsuno Cheeclaw.

The gang go on vacation in Westward City and are attacked by One-Eyed Jack and get help from a stranger who knew Jeredy Suno.

Chase's visions are getting more intense, while Beyal's are disappearing. Dom Pyro returns to make the team into trophies.

Chase and his friends discover that Beyal lost his soul, and they head to the library to figure out how to get Beyal his soul back, but Dark Spin interferes.

Chase and the rest of the Core-Tech team has discovered The Valley of the Five Tribes, but so has S.T.O.R.M. and the Eklipse Organization.

Stemming from one of Beyal's visions, Chase discovers his mother is still alive. Seeking answers from his father, Chase forces Dax to take him to Jeredy's location. While the Suno's talk, S.T.O.R.M. attacks and captures Jeredy.

Dax tells the rest of the Core-Tech team what he knows about Jeredy, which leads Bren discovering Jeredy's plan. During an attack by Jack on the Core-Tech team, he reveals the full scope of his mission to the Core-Tech team and later the rest of the world.

The Core-Tech team gets a message that Dark Spin is chasing Jeredy, the Core-Tech team go to help. Afterwards, S.T.O.R.M. once again captures Jeredy.

Following Chase's plan, the Core-Tech team seek to free Jeredy from the clutches of S.T.O.R.M.

After Jeredy and the Core-Tech team place the last failsafe device, they are attacked by the Eklipse Organization . They discover that Jeredy and Chase's friend Jon Ace had survived the explosion, but was reborn as a Monsuno by Eklipse, and Jeredy is captured.

Using Jack as a diversion and with help of Dawnmaster, Chase plans to break into Eklipse Organization headquarters and free his father once and for all.

An all out battle takes place between the Eklipse Organization, Core-Tech, and S.T.O.R.M. The battle ends with Core-Tech's victory and Lock is fused with another of Chase's Monsuno's by Eklipse's base exploding. Afterwards, Jeredy gives Chase the trigger switch to decide the fate of the Monsuno. However, believing there could be a way for Monsuno and humans to live in peace, Chase throws the trigger switch away.