When beloved store manager 47-year-old Mary Peterson is found stabbed to death in her bed in 1995, storm clouds brew over sunny Lakeland, FL. Cops race through a lengthy list of suspects, but a tip from an unlikely source helps nab the cold-blooded killer.

On April 15, 2004, residents of Riverton, WY are worried about more than the IRS after the brutal murder of 39-year-old prison nurse, wife and mom Tammy Watts. Police begin an all out manhunt for the killer and it takes a hair-raising discovery for them to nab their guy.

When 12-year-old Michelle Winter goes missing without a trace while walking back from her best friend's house in Springfield, MO in 1995, her mom doesn't have a clue as to who could have whisked this pre-teen away. Cops have many leads, but it isn't until evidence is linked to the killer that they get their big break.

The tight-knit community of eastside Buffalo, NY is stunned in 1994 when the body of beautician and single mom Cynthia Epps is found stuffed into a cabinet placed in a neighbor's backyard next to a vacant lot cut-through; she had been raped, stabbed and nearly decapitated. A clever killer eludes capture for 16 years, but new technology and dogged detective work put him behind bars.

When a sip from the office water cooler turns deadly for secretary Julie Williams in 1986, detectives in Tempe, AZ are stumped. Who could have had it out for this sweet single mom? Investigators search for the mystery mixologist and are shocked at who they stir up.

In late 2007, Jasper, TX, native Martin Byerly disappears without a trace. Police look into the 58-year-old ladies man's dance card but can't seem to pin anything on a femme fatal. Then an unlikely tipster helps them learn what happened to Martin.