Medical examiner Holli and homicide detective Mack investigate the death of Holli's former lover and the relationship between a dead Asian woman and a private security firm.

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A U.S Marshall with whom Holli has previous involvement is paid by an obstreperous Colombian drug lord to kill a mob hit-man in witness protection and switch the hit-man's identity to the Colombian.

A man trying to hide an affair and special forces operative stalking his ex-wife escape Holli's attempt to contain for inoculation the passengers of a flight on which a man has died of bacterial meningitis.

Holli and Mack are prompted by personal requests to investigate two different deaths deemed natural as murders for insurance payouts.

The offices of the D.A. and Medical Examiner offices are frustrated by preferential treatment given a popular island singer accused of murder at the same time an elite defense team tries to demean Holl's forensic evidence including DNA.