Season 0 of Fullmetal Alchemist: Brotherhood premiered on August 25, 2009.

The specials consist of five episodes that expand on moments and characters from the main series. These short episodes offer a mix of humor, emotional depth, and additional backstory, enriching the overall narrative. In "The Blind Alchemist," Edward and Alphonse investigate a man who claims to have performed human transmutation, only to uncover a tragic secret. "Simple People" is a lighthearted episode featuring Winry and Riza Hawkeye, where Winry strives to improve her automail skills. "The Tale of Teacher" reveals the backstory of Izumi Curtis, the brothers' alchemy teacher, showing the struggles she endured. "Yet Another Man’s Battlefield" explores Roy Mustang’s experiences during the Ishvalan War, emphasizing his ambition and the emotional weight of his decisions. Lastly, "The Chronicle of Teacher" offers a comedic look at Izumi's training, showcasing her determination and fiery personality.

Season 1 of Fullmetal Alchemist: Brotherhood premiered on April 4, 2009.

Brothers Edward and Alphonse Elric suffer a tragic loss after attempting forbidden alchemy to bring back their deceased mother. Edward loses a leg and an arm, while Alphonse's body is entirely taken. To save his brother, Edward binds Alphonse's soul to a suit of armor. Now, the brothers seek the Philosopher’s Stone to restore their bodies.

Edward becomes a State Alchemist, and they face threats from Scar, a vengeful warrior, and the Homunculi, mysterious enemies linked to the Philosopher's Stone. As the season unfolds, they uncover deeper mysteries about the Stone and the dark forces controlling it, while their journey tests their bond and moral beliefs.