Season 0 of Slayers premiered on July 25, 1996.

Season 1 of Slayers premiered on April 7, 1995.

Powerful, avaricious sorceress Lina Inverse travels around the world, stealing treasures from bandits who cross her path. Her latest victims, a band of thieves, wait in ambush in a forest, thirsting for revenge. When Lina is about to effortlessly pummel her would-be attackers, the swordsman Gourry Gabriev suddenly announces his presence. Assuming Lina to be a damsel in distress, the foolish yet magnanimous man confronts the brigands in order to rescue her. After defeating them posthaste, the oblivious cavalier decides to escort Lina to Atlas City. Though not very keen on this idea, she ends up accepting his offer.

However, without realizing it, Lina has chanced upon a mighty magical item among her most recent spoils. Now two mysterious men are hunting the young magician and her self-proclaimed guardian to obtain this powerful object for apparently nefarious purposes. This way they begin their adventure, one where the fate of the world itself may be at stake.

Season 2 of Slayers premiered on April 5, 1996.

In the kingdom of Xoana, Lina Inverse and Gourry Gabriev unexpectedly come across their old companions, Zelgadis Graywords and Princess Ameilia Wil Tesla Saillune. Upon their reunion, the friends end up easily foiling the King of Xoana and his daughter's dastardly plans of world conquest.

Soon after, it is revealed that Zelgadis is in search of the world's most valuable magical tome, the Claire Bible, hoping to discover a method to recover his human body among the many secrets sheltered within it. Despite his protests, the rest of the group decides to join in the quest after hearing of his mission. However, just when they were wondering where to start looking for the legendary book, they stumble upon a mysterious priest by the name of Xellos, who claims that he may be of some help in their pursuit.

Season 3 of Slayers premiered on April 4, 1997.

For nearly a millennium, demons have imposed a magical barrier that has impeded the people trapped within it from reaching the outside world. Now that it is broken, several kingdoms seek to explore the lands that were once beyond their grasp. To this end, they establish a peace delegation to make contact with the inhabitants of the new world.

Meanwhile, the young sorceress Lina Inverse receives a message from a mysterious woman named Filia ul Copt. When they meet, Filia expresses interest in hiring Lina and her friends, having heard of their great deeds, for a certain task that will take them to the outside realm. Despite that, Filia feels the need to put their strength to the test and pits them against a dragon in the middle of the city! After proving themselves, the sorceress and her fellow adventurers set off for the unexplored lands, where many adventures and a worrying prophecy await them.

Season 4 of Slayers premiered on July 2, 2008.

Having lost the Sword of Light in the previous battle, Lina and Gourry continue their journey in search of a replacement weapon. On the way, the two of them meet up with Amelia and Zelgadis in the kingdom of Luvinagard while taunting some pirates. Lina is happy to reunite with her old friends, but appearing before her is Luvinagard's Inspector of the Special Investigative Unit; a man called Wizer. However, Lina is amazed at his unusual behavior...

Season 5 of Slayers premiered on January 12, 2009.

To find a way in rescuing Pokota's country Taforashia which was sealed by Rezo, Lina and her group are in search for the Hellmaster's jar in what the Red Priest placed his soul after death. Zelgadis is willing to do anything to get the jar for changing back into a human while Zuuma is plotting on revenge and accomplishing assignment in killing Lina Inverse. Still a big mystery for her and the others is what Xellos is aiming for in this battle.