The wandering physician Ye Pingan, entangled in an old and secretive case, arrives in Chang'an. Accused of mystical medical interventions, she manipulates minds and evokes fear, while the low-born magistrate Yuan Shaocheng, craving power, seizes the opportunity to rise. A murder in Chang'an implicates Ye Pingan, but is she truly an innocent scapegoat or a mastermind plotting revenge? The first move in her intricate scheme has already unraveled.

江湖游医叶平安因一起隐秘的旧日疑案寻至神都洛阳，因几桩诡谲离奇的出诊案件而背上巫医之名，她擅用心计，蛊惑人心，人人避之而不及。大理寺丞元少城因出身贱民区，被视作“臭老鼠”，纵有一身才能却无法得到尊重，他渴望权力，阴险狠戾，时刻捕捉着爬上高位的机会。此时，洛阳城中发生一桩命案，一位大人惨死于家中，他不仅死前请叶平安来府上看过心疾，并且只有叶平安一人出现在命案现场。元少城负责此案，虽看出蹊跷，但为了利益仍将叶平安置于死地，以达成自己晋阶的“投名状”。叶平安怎么看都只是这个凶杀案里的无辜替死鬼，然而事实真是这样么？谁也想不到，叶平安已经在她的复仇之路上，下出了布局的第一颗棋。