In 1906 London, the casualty room of the London Hospital deals with a wide variety of cases. As a charity hospital, they refuse no one and are also located in the East End where the working poor are in the majority. The cases include a man whose tried to take his own life; a young boy, Teddy, with rickets; and a Russian immigrant and supposed anarchist, Abraham Goldman, who was beaten by the police. Mr. Wilson is a pioneering radiologist and has been amazing everyone with his revealing use of x-rays. He's paying a heavy price however. Nurse Mary Green is dismissed because of her relationship with a doctor. When Nurse Ada Russell is seen in public with Dr. James Wilson by a young colleague, Probationer Eastwood, she now fears for her own future. When Matron Luckes discusses the situation with Ada, she makes a surprising offer. The hospital has to battle an outbreak of infection in one of the wards.