In 1906 London, the casualty room of the London Hospital deals with a wide variety of cases. As a charity hospital, they refuse no one and are also located in the East End where the working poor are in the majority. The cases include a man whose tried to take his own life; a young boy, Teddy, with rickets; and a Russian immigrant and supposed anarchist, Abraham Goldman, who was beaten by the police. Mr. Wilson is a pioneering radiologist and has been amazing everyone with his revealing use of x-rays. He's paying a heavy price however. Nurse Mary Green is dismissed because of her relationship with a doctor. When Nurse Ada Russell is seen in public with Dr. James Wilson by a young colleague, Probationer Eastwood, she now fears for her own future. When Matron Luckes discusses the situation with Ada, she makes a surprising offer. The hospital has to battle an outbreak of infection in one of the wards.

December, 1907. In East End, wealthy metropolis London's poor side, London Hospital depends on private charity to finance its care of the poor. A Christmas party is prepared by staff for patients and benefactors. The influx includes Jewish laborers wounded by police while demonstrating and young Teddy who was bitten at home by rats. A wound infection untreatable until the invention on antibiotics kills like an epidemic. Matron Eva Luckes still fires nurses for affairs with doctors. A tragic case is the pioneering X ray research operator, whose radiation-burned fingers...

The hospital is dealing with a major gastro-intestinal infection that is proving deadly. They have lost as many as 14 children in one night and it's taking its toll on all of the staff. The hospital Chairman, Sydney Holland, estimates that given its current financial situation, the London Hospital will be forced to close in 5 weeks. He gets bad news from Lord Rothschild, one of the London Hospital's most generous supporters. Nobby Clark, a local gang leader, is back in the receiving room and Dr. Culpin decides to admit him this time. Ethel Bennett has been assigned to...

Sydney Holland already fears bankruptcy and now most Jewish benefactors intend to start a ghetto hospital instead. A hot May causes killer diarrhea among slum kids. 'Beggar's gang member Nobby is hospitalized for liver cirrhosis. Bedford Fenwick chooses Dr Lawes is chosen for a more lucrative position over Dr. Millais Culpin who fails only as- drinking chum.

In turn-of-the-century London, the staff of the London Hospital treat a variety of patients. It was also one of the first hospitals to use anesthetics regularly. With little in the way of health and safety regulations, they must deal with the victims of industrial accidents including one worker who suffers terrible burns. They also treat a large number of injured following what is believed to be a bomb explosion while the police push their way in and insist on questioning the patients. The hospital allows the investigation to go forward even though it turns out to ...

Sister Ada Russel has her first day as the head of the Receiving Room. Nurse Ethel Bennett is informed by the Matron that she is being transferred from the Receiving Room to the private care service. Bennett isn't too keen, but has little choice and accuses Ada of trying to get rid of her. A patient who attempted suicide is soon carted away and charged by the police. A patient in for the removal of a cancerous testicle loses all feeling in his legs, possibly a reaction to the use of a local sedative, Stovaine. He was Mr. Dean's patient and Nurse Laura Goodley reports ...

The hospital continues to deal with what appears to be a never-ending flood of patients. Among those are new immigrants who, in an attempt to better their lives, flock to London. The result for the hospital is having to treat the diseases they bring with them. A case in point is a young boy admitted with polio, which is non-existent in the UK. The boy is brought in by Saul Landau, an atheist and a socialist who himself is admitted with a rare condition. As an atheist, he objects to being admitted to the Jewish ward but soon takes an interest in Nurse Laurey Goodley. ...

The hospital finds itself invaded by a group of anti-vivisectionists and the object of a well-orchestrated letter writing campaign against the hospital's research practices. Mr. Holland is worried about how the charitable institution will continue should donations decline substantially. The hospital treats a woman who appears to be poor and attempted suicide. The suicide attempt was real but the woman it turns out is a well-known stage entertainer, Grace Barnes. Dr. Head gladly treats her as he has his own theories about mental incapacity and its effect on physical ...

The receiving room doctors treat a woman who has obviously tried to terminate her pregnancy, very much an illegal act in 1909 England. Dr. Culpin is sympathetic despite the legalities of the situation and Sister Ada Russell takes an interest in the woman's well-being. Nurse Ethel Bennett rushes off to a Naval hospital where her brother is recovering from an appendicitis operation he underwent in South Africa. What she finds there is filth, malnourishment and a lack of modern facilities and medicines that is shocking given the sacrifice these men have made for their ...

Mr. Dean has overcome his addiction to cocaine and returns to work. Unfortunately, he loses his nerve in the middle of an operation leading Mr. Holland and Mr. Fenwick to suspect that he may have suffered permanent damage. Sister Ada Russell continues helping a single mother with several children but the long hours are taking its toll and she is late for her shift in the receiving room. Matron Luckes admonishes her and suggests she re-examine her priorities but Ada is clearly questioning the choices - spinsterhood, no children - that come with being a nurse. They face...