At the Young Inventors Expo, Penny unveils her latest invention (the Gadgetinis were her entry the previous year) a DNA tracker which can find anyone. Her friend Shawn shows off his invention an invisibility spray and is abducted by MAD Agents since Dr. Claw thinks the sprayer could be useful. While Gadget and the Gadgetinis are stumbling around, Penny finds Shawn but gets herself trapped in the MAD lab. So, the two young geniuses have work together to escape.

Dr. Claw seems to have reformed and has become the new CEO of the humanitarian organization GloboCare. Gadget believes he's changed but Colonel Nozzaire (and Penny) suspects he's secretly plotting something and sends Gadget to GloboCare to investigate undercover.

World leaders are to meet at a peace conference in Phasia, the most peaceful and happy country in the world ruled by the always smiling General Zarnoff. Gadget is sent to take care of security and finds nothing amiss but Fidgit and Didgit discover unhappiness is a crime and there are severe penalities for citizens who don't smile all the time. Add to that the fact that General is secretly stockpiling weapons and it's obvious to everyone except Gadget that something is rotten in Phasia.

Gadget is sent to Paris to protect the world's most famous (and only) canine artist "Roverre". Meanwhile, Dr. Claw intends to abduct the dog and make him teach Mad Cat how to paint so he'll be the world's only animal artist and people will pay millions for his paintings.

After suffering a serious attack of stress-induced pimples, Colonel Nozzaire decides to take his therapist's advice and keep Gadget as far away as possible with work missions. So, he sends Gadget to Hong Kong (the first place he thinks of) to buy office supplies for WOMP. Meanwhile, in Hong Kong, control of the Banan business empire has just passed to Amanda Banan as a graduation present from her father. Amanda's being targeted by Dr. Claw who wants control of the corporation and thinks she'll be easier to crack than her father. MAD agents are sent in to infilitrate the headquarters of Banan Communications and take over the top two floors, which is how Amanda finds herself on the roof tied to a satellite dish with the choice of signing control of the company over to MAD or being roasted by a high power transmission that's due at noon. Thanks to one of his usual mixups, Gadget is wandering through the building convinced it's a stationary supplies warehouse.

Gadget is sent to Switzerland to protect a fleet of "subatomic" (?) atomic sumbarines concealed in Lake Geneva while they await decommissioning. Unfortunately MAD agents have already infiltrated the subs crews.

Marcus I, the King of Oblivia intends to put his obscure country on the map by relocating the Great Wall of China to Oblivia. Meanwhile, Gadget thinks a group of Shaolin Monks are responsible for its disappearance and tries to challenge them to a Kung-Fu showdown.

Gadget is assigned to find the missing Colonel Nozzaire, but it turns out the Colonel was abducted to lure Gadget into a trap. Gadget is converted to binary data and sucked into a videogame where Dr. Claw intends to destroy both him and Nozzaire.

Gadget is successfully abducted by MAD Scientist Dr. Von Headcase who intends to brainwash him. Penny spends a week trying to locate him. Having exhausted all her computer resources and knowing that Colonel Nozzaire isn't seriously looking for her uncle, she turns to the only person in the world who might be able to help - the now retired and gadget-phobic Brain.

WOMP unveils Super Gadget Girl (but since that's a bit long everyone calls her Super GG or just GG), a state of the art fembot who is tougher and smarter than Gadget. But unlike him she's entirely machine with programmed emotions and programming can be changed, which Dr. Claw intends to do so she'll steal the world's gold reserves for him and eliminate Gadget once and for all.

Albert Alkaline (aka AA), the world's major battery manufacturer, is worried that MAD intends to kidnap and ransom his extreme sports fanatic son Alan Albert Alkaline (aka AAA). Since he's offering a large reward and WOMP is low on funds again Genral Sir agrees to protect AAA. After hearing that all the other bodyguards AAA had got mangled trying to keep up with him during his extreme sports events, Colonel Nozzaire is happy to assign Gadget to the case.

The 10 biggest banks in New York have been robbed but despite the break-ins happening in broad daylight there are no eye witnesses, the security cameras shut down and no one can remember what happened. The only clue is that everyone who was in the banks remembers hearing bagpipe music before the robbery. The police have no clue so WOMP is called in and Gadget is sent to Scotland accompanied by Penny & the Gadgetinis to investigate the only clue - a security camera closeup of the name McIntosh's Magic Bagpipes Inc. on the pipers bagpipes.

All over the world valuable items are being stolen by mysterious thieves who elude capture by dissolving into lines of computer code along with the stolen goods then vanishing without a trace. When they vanish they're returning to the Patrix, a virtual world created by a MAD scientist who has discovered how to send things from the Patrix to the real world and vice versa. His computer generated thieves can pass for humans until they're ready to strike and can look like anyone making them the perfect infiltrators. The scientist's assistant didn't like his boss selling out to Dr. Claw and wants to stop him so he's looking for "The One" who can detect and defeat the Patrix people. He thinks Gadget might be The One but Gadget thinks he's being selected as a finalist in a gardening competion!

MAD scientist Dr Pause switches his assistant Guy Strong's brain for Gadget's then sends him off to WOMP to get the info he needs to switch the brains of the world's top generals. Meanwhile, Gadget accidentally escapes the deathtrap intended to destroy him in Guy Strong's body but is clueless about what's wrong with him. Penny and the Gadgetinis attempt to capture Gadget's body but Strong can work Gadget's gadgets and quickly overpowers them and leaves them tied up next to a bomb. Just to complicate things further Dr. Pause is planning to switch Guy's brain again, this time with General Sir's secretary Ms. Miffet.

Colonel Nozzaire's idol, the famous TV Cook "The Silver Chef", is to prepare a meal for the president, but Gadget gets the assignment to make sure MAD doesn't poison the food the chef prepares. Unfortunately, the Silver Chef is a MAD agent and intends to get rid of Gadget and poison the president.

Gadget & Colonel Nozzaire are sent to the Colonel's old desert Foreign Legion post to investigate rumors of female criminals converging on the area. What they don't know is that Dr. Claw's archeologist, Professor Suzuki, is looking for a lost temple holding an ultimate weapon that requires 12 women to unseal it.

The tiny Himalayian country of Goldmanchu's only export is the gold created by the midas touch of the simpleminded mystic Golda (whose right hand turns things to gold and left hand turns things to wood). Golda's existence was a closely guarded secret but WOMP fears Dr Claw has learned of him and intends to use his golden touch to destabilize the world's economy so Gadget is sent to Goldmanchu. Unfortunately, Golda has already been replaced by an imposter with orders to eliminate Gadget.

With General Sir in the hospital and Colonel Nozzaire finally getting a field assignment trying to track down Dr. Claw, there's no alternative but to make Gadget the acting head of WOMP. While Gadget uses General Sir's secretary Miss Miffet as a model for his ideas for new WOMP uniforms, Colonel Nozzaire is captured and brainwashed to recommend that the Board of Megapowers shut down WOMP. Can Penny and Chief Quimby work together to get Gadget to save WOMP?

Dr. Claw has a MAD scientist build a time machine then travel back to 1957 to prevent Gadget's parents Jules and Annie from meeting. Back in the 21st century, Gadget begins to fade away and so does Penny and the Gadgetinis since she can't exist without her grandparents and if she's never born there's no one to build them. While the scientist delays Jules, he still manages to crash his bicycle into Annie's and everyone reappears. The Gadgetinis and Gadget travel back in time to find the scientist who gets Gadget locked up but Gadget breaks out of the police station accompanied by his cellmate Marilyn, who was destined to meet Gordon Claw in the holding cell and eventually become Dr. Claw's mother. So, now the scientist has to try and get them together while breaking up Jules and Annie's budding romance and the Gadgetinis have to stop him.

General Sir thinks MAD might kidnap global rock and roll superstars "The Mummies Boys", so Gadget is sent to protect them. Since the Boys are Penny's favorite band, she tags along, unaware that Dr. Claw has bigger plans. Backstage at the stadium for their soon-to-air global concert, Penny overhears their new Soundman talking to Dr. Claw about putting a mind control signal into the broadcast which will be watched by about 2 billion people. He spots Penny and leaves her tied up in a trunk. Meanwhile, the opening act "Pharoah's Men" is booed offstage so they load up their bus and leave taking Penny in the trunk with them. Turns out Penny's wristwatch still has the laser from the original series so she cuts herself free then persuades the band to go back and save the crowd who rejected them. Meanwhile, the Soundman arranges to eliminate Gadget with the show's special effects during the concert and as always Gadget is oblivious to the danger.

A microscopic implant has been detected in the brain of General Gastritas. It's suspected to be a MAD mind control device and since he's about to be made Supreme Commander of the Mega Powers militaries, WOMP can't afford to take chances. So a volunteer is needed to be miniaturized by an experimental process and injected into the General's Brain to remove the device. It's a one in a millon chance of surviving the mission so Colonel Nozzaire is happy to volunteer Gadget. Gadget, the Gadgetinis and the Gadgetmobile are shrunk and injected into the General's skull to face angry white blood cells who don't like intruders and miniaturized MAD agents ready to defend the mind controller. Just to complicate things further, the scientists made a miscalculation when they shrank them and they have only a few hours rather than days before they return to normal size.

Colonel Nozzaire is a budding archeologist and author who has just written a book about the Aztecs. Too bad nobody's coming to his book launch except Gadget with news from General Sir. A recent earthquake in Mexico unearthed the entrance to the lost underground Aztec City of Gold. Rumor has it the Aztecs hid their "Crown of Invincibility" in the city and it's a prime target for MAD so WOMP has to find it before Dr. Claw uses it to become unstoppable. Colonel Nozzaire, Gadget, the Gadgetinis and an Archeologist descend into the city while Penny's left back at the base camp. She overhears assistant archeologist Ron Limond talking to Dr. Claw about how he found and hid the map to the secret entrance & shortcut tunnel that avoids all the traps. He heads off to the City and Penny breaks into his safe to find the map but Ron returns to pick up the crowbar he forgot and catches her. Ron forces Penny into the secret entrance tunnel and beats Gadget to the underground city's treasure vault.

Colonel Nozzaire decides to try and follow his bossy therapist's advice and keep his temper no matter what Gadget does wrong. Too bad for him that a mad scientist looking to become Dr. Claw's partner has chosen him as the prime target for his anger enhancement beam so that he'll destroy Gadget for them. While the hulked-out Nozzaire keeps failing, there are plenty of other people in town the scientist can make want to destroy Gadget - including a florist who owns some man-eating plants that don't mind chewing on robots too.

Dr. Claw's mother (the one person in the world he fears) orders him to take care of his nephew Billy while he's on summer vacation from his boarding school. She also tells him that Billy is unaware of their family's criminal history and that's the way she wants it to stay. Far as Billy knows, he's being sent to stay with his Uncle Gordon, a wildlife biologist studying the animals on a tropical island. So that's what he tells Penny when he meets her at the airport when she arrives on the same island for a camping vacation with her uncle. Gadget's arrival infuriates Dr. Claw and gives him the problem of how to eliminate his enemy while keeping his nephew from knowing he was involved in Gadget's demise. Fortunately, his experiments on controlling the wild animals of the island offer a solution.

The unicorn comet approaches Earth for the first time in 777 years, which was also the last time unicorns were seen. The comet is putting out a magnetic field which affects electronics and Penny is worried her uncle might go haywire, but as the Gadgetinis say, how would you tell? Meanwhile, MAD's astronomer tells Dr. Claw that the comet's magnetic field also scrambles the natural invisibility field that unicorns can generate, which is why they're so rarely seen and why the last sightings were during the comet's last visit. Since unicorn milk is reputed to grant superhuman strength, Dr. Claw would like to find some to make his MAD agents superstrong. Back at Gadget's house, the Gadgetinis' programming has become corrupted and so have they, as they refuse to do any more work without substantial rewards. Dr Claw contacts them and promises them riches if they dispose of Gadget and catch him a unicorn and they agree.