The S and M Comic Book was a Canadian series of four sketch comedy specials, that aired on CBC Television in 1985 and 1986. Starring Greg Malone and Tommy Sexton, the series evolved out of the pair's touring show Two Foolish to Talk About.

The series won several Gemini Awards in 1986. Instead of expanding Comic Book into a permanent series, Malone and Sexton worked with their colleagues Mary Walsh, Andy Jones and Cathy Jones to develop the CODCO series, which began airing in 1987.