Barangay 143 follows the coming of age story of a young man in search of a father and how he finds an unlikely family in a team of misfits trying to bring glory to their hometown. It's a story about love and family set against the action-packed world of street basketball, where the stakes are always high and life is the biggest game you can win.

Dalawang taon bago magsimula ang serye, si Roberto "Coach B" Sebastián, ang anak ni Sr., si Roberto "Basti" Sebastián, Jr., ay pinatay ng isang mamamaril mula sa isang malaking sindikato na nagpabagsak sa pangkat ng Powerhouse ng Barangay 143 at nanguna. sa mga kaganapan ngayon. Si Bren Park, isang manlalaro ng Korean basketball team, ay nawalan kamakailan ng kanyang pamilya sa isang trahedya na aksidente sa panahon ng snowstorm sa South Korea na nagbunsod sa kanya na huminto sa basketball. Gayunpaman, kasunod ng isang pagbubunyag na siya ay anak ng kanyang ina sa isang Pilipino, nagpunta si Bren sa Maynila upang hanapin siya. Sa daan, sumali siya sa isang lokal na basketball team, ang Puzakals ng Barangay 143.

ขณะที่โค้ชบาสกำลังเสียใจกับการสูญเสียลูกชาย นักบาสคนดังจากเกาหลีก็เดินทางมาเยือนมะนิลาและได้พบสมาชิกทีมบาสจากต่างที่มา จนกลายเป็นเสมือนครอบครัวที่จะสู้เพื่อชัยชนะด้วยกัน