The true story of John Romulus Brinkley, a small-town Kansas doctor who discovers in 1917 that he can cure impotence by transplanting goat testicles into men. And that’s just the tipping point in this stranger-than-fiction tale. With the balls of a P.T. Barnum, the gonads of goats, and the wishful dreams of flaccid men, Brinkley amassed a fortune, was almost elected Governor of Kansas, invented junk mail and the infomercial, and built the world’s most powerful radio station. By the time all of the twists and turns of Brinkley’s story are revealed, Nuts! certainly earns its title.

同樣喜歡追求刺激的珍妮和拉娜是感情非常要好的死黨，火辣的珍妮對男人有著著魔般的狂熱，而拉娜雖為一名家庭主婦，但強悍的個性和高超的賭博技巧也多次讓她在牌桌上大賺一筆。一次因緣際會下，拉娜透過莊家拉比結識了幫派老大卡希姆，在見識過拉娜絕佳的牌技後，卡希姆決定派她參加一場獎金優渥的世紀賭局，但一向自信滿滿的拉娜卻在這次失了手，面對欠下龐大的賭金及心狠手辣的卡...

　　宾克利医生本来在堪萨斯州执业，有个农夫病患深受阳痿之苦，只能羡慕公羊每天「性」致勃勃。两人突发奇想，何不把公羊睪丸移植到农夫身上？结果农夫不仅重振雄风，还一举得子。妙手神医传遍千里，宾克利成了回春救星，他不仅赚了大钱扩建医院，还经营公羊牧场，提供患者配对选择；甚至成立电台，宣传他的神奇植入术。口若悬河的电台卖药始祖，与听众亲切互动，名医又变成空中张老师。 　　导演佩妮莲恩除了邀请各界专家来解剖宾克利这个充满争议的人物，更大量使用手绘动画再现当时的事件场景。类剧情片的叙事手法不仅挑战传统纪录片，也像在提醒观众，说不定电影本身也是一场骗局。令这部妙趣横生的奇片，更多了思辨的空间。