A comedy about the everydaylife of the 30-year-old something nurse Henriette and her life. Her boyfriend is boring and she has an affair with a violent doctor. She shares an apartment with a gay man and she is close with her brother who is a somewhat insecure and love-seeking guy. However, after some unfortunate clashes with the world, Henriette realizes she is able to stand on her own.

Sygeplejersken Henriette og overlægen Henrik Løwe har indleder en hed affære. En fælles rejser til Afrika er en fiasko, men de fortsætter et forhold, hvor Henrik viser nye ubehagelige sider af sin personlighed. Henriette er ulykkelig, men forøger at få hjælp fra sin bror Ole og sin selvopgtagede homoseksuelle bofælle Bent.