The main character in Human Bone Wine is Truong Tu Kiet (Lu Han Dinh), a guy who decides to join a tour on a deserted island with his friends to forget the pain of his girlfriend Ava's (Vien Le) sudden death. Lam). But the journey to the wilderness was not as fun as expected. The four friends begin to see strange things, then scary supernatural events happen one after another. Not long after, they discovered the existence of an ancient evil force and it was lurking and following them wherever they went. What seemed like a fun trip turned into a deadly horror.