It was called the Black Death, a disease that started in the 14th century, and swept across Europe wiping out half the population, one of the most lethal killers in human history. But the cause of the Black Death has eluded scientists. Now, Evolutionary biologist Hendrik Poinar embarks on an epic journey to solve the 600-year old mystery and change the way we fight infectious diseases today.

After a painting that was previously owned by Ludvik's grandfather mysteriously starts to move by itself, Ludvik and Amund decide to go to where the painting originated from, and what they found should never see the light of day.