On 19 December 2005, just seconds after takeoff from Miami, Florida, the right wing of Chalk's Ocean Airways Flight 101 breaks off, causing the aircraft to crash into the sea, killing all 20 people on board. The causes of the crash were metal fatigue and poor maintenance.

On 19 July 1989, the tail-mounted number two engine of United Airlines Flight 232 explodes, causing serious damage to the aircraft's hydraulic systems and leaving the flight controls unusable. By varying engine thrust, the pilots manage to crash-land the aircraft at the Sioux Gateway Airport in Iowa, saving the lives of 185 of the 296 people on board. The investigation traced the engine failure to a fatigue crack in the front fan disk which had developed from a defect introduced before the disk was even made, when the original titanium ingot used to make it was formed.

On 25 January 2010, Ethiopian Airlines Flight 409, en route to Addis Ababa, plunges into the Mediterranean Sea shortly after takeoff from Beirut–Rafic Hariri International Airport during a thunderstorm, killing all 90 people on board.

On 1 June 2009, Air France Flight 447, a scheduled flight from Rio de Janeiro to Paris, stalls and crashes into the Atlantic Ocean while flying through a thunderstorm, killing all 216 passengers and 12 crew members on board. The causes of the crash were incorrect airspeed readings due to ice blockage of the aircraft's pitot tubes, inappropriate control inputs and the pilots not taking recovery action until it was too late.

On 27 June 1980, Aerolinee Itavia Flight 870 crashes into the Tyrrhenian Sea near the island of Ustica, Italy. All 81 people on board are killed. The top Italian criminal court eventually ruled on 23 January 2013 that a missile strike brought down the aircraft,[7] but controversy remains; some experts dispute this conclusion, arguing that an on-board bomb in the rear toilet was the cause. No definitive accident report was published.

On 27 November 2008, an aircraft on a post-maintenance test flight operating as XL Airways Germany Flight 888T crashes into the Mediterranean Sea off the coast of France, killing all seven people on board. The investigators determined that improper maintenance work allowed water to enter the aircraft's angle of attack (AOA) sensors. The water then froze during flight, causing the sensors to stop working. The crew tried to test the stall warning system during flight, and the aircraft entered a low-speed stall.

On 25 July 2000, a Concorde operating as Air France Flight 4590 en route to New York City, USA, stalls and crashes into a hotel in Gonesse shorty after take off from Charles de Gaulle International Airport. The plane had struck foreign debris from a Continental Airlines DC-10 causing the plane's fuel tanks to ignite and the engines to fail. All of the 109 passengers and crew die in the incident and 4 on the ground.

On 4 November 2008, an official Mexican Interior Ministry Learjet 45 crashes in central Mexico City. Mexican Secretary of the Interior Juan Camilo Mouriño, who was aboard the plane, was killed in the crash, along with the other seven people on board and eight people on the ground. The plane crashed in rush-hour traffic at Las Lomas. The plane crashed due to a loss of control from wake turbulence.