London, 1899. Three years after an inexplicable event suddenly equips them with extraordinary abilities, Amalia True and Penance Adair work to protect their kind from widespread, deepening antipathy. Meanwhile, police inspector Frank Mundi investigates a string of murders at the hands of a reportedly Touched and highly dangerous serial killer named Maladie.

As the city buzzes with anticipation over a pending execution, Penance grapples with a moral calling at odds with Amalia's plan. With the two women at a crossroads, the Orphans must decide whom to follow.

Horatio faces tests of loyalties, while True and Penance prepare for what's coming.

The men seek to control the Touched.