The first episode starts from the work of a genius symbol of national creativity: the Last Supper by Leonardo da Vinci. Alberto Angela will illustrate its history and importance, while Philippe Leroy, the unforgettable interpreter of the television Leonardo, will remember the emotion he felt in taking on the role of the painter. From Leonardo's Milan you will go to the heart of Tuscany, to Siena, an entire city recognized as a world heritage site. From Piazza del Campo to the Palazzo Pubblico, from the Cathedral to the Historical Archives, there are many splendors that the host will propose to viewers. A true Sienese, Gianna Nannini, will revive the character and passions that animate the city and its inhabitants. It ends in Sicily, in the splendid "Valley of the Temples" of Agrigento, which has always been a destination for Grand Tour travelers in search of the art and culture of Magna Graecia.