A young boy prostitute is butchered on the Williamsburg Bridge, alienist Laszlo Kreizler, newspaper illustrator John Moore, secretary Sara Howard & police commissioner Theodore Roosevelt investigate outside the law to find a serial killer.

Innovative evidence leads the team to discover a crucial element in the case is missing. Kreizler and Moore interview a witness to find out what happened to Moore at the Brothel. Sara attempts to live in a world outside the investigation. Kreizler challenges them to look within themselves.