Desna and her girls take pride in doing nails at the Nail Artisans of Manatee County, but amidst painting hooves and dreaming of a better life, she finds herself entangled in a money laundering scheme with the Dixie Mafia.

After the big nail competition, Desna may finally get out from Uncle Daddy's grasp. Jennifer struggles knowing Desna's dark secret, while Polly discovers her previously unknown maternal instincts.

With a shocking revelation affecting the entire crew, Jennifer finds unexpected solace in her square-dancing instructor. Polly uses all of her powers of bad for good, for the first time, while Quiet Ann is torn about a big decision.

Desna goes searching for the truth with her crew right behind her, save for Jennifer, who is learning how to cope as a Dixie Mafia wife. When Desna's sleuthing hits pay dirt, she goes to the only person who can save her. Time is running out.

Following a harrowing escape from Roller's grasp, Desna is on the run. Roller is close behind, running from the Russians. In the end, only Desna can save Jennifer, Roller, and her crew with a sacrifice greater than any she's ever had to make.