A nightclub is used by vampires to trap unsuspecting guests and feed on them. Just as the feast is about to start, Blade arrives looking for the ancient vampire who long ago infected his mother - Deacon Frost. However, he gets company.

Sakomizu, a middle-aged police detective in Osaka, is troubled by a recent series of missing Southeast Asian women. After he meets up with Blade, they discover that the chief of police is helping to provide local vampires with human blood.

Blade has no choice but to fight the mutant assassin, Kikyo Mikage. While fighting, they remember the time when they were studying sword fighting together under the same master. However, their old master suddenly appears - now a vampire.

While in captivity and pushed to his limits, Blade struggles to regain control of himself as his allies attempt a daring rescue. Ironically, this gets Frost closer to his goal and Blade loses a friend. The vampire council is next.