A nightclub is used by vampires to trap unsuspecting guests and feed on them. Just as the feast is about to start, Blade arrives looking for the ancient vampire who long ago infected his mother - Deacon Frost. However, he gets company.

Blade invades Amaurot, the City of Vampires and headquarters of Existence, while cutting his way through anything that stands between him and now evolved Deacon Frost. Frost's monstrosities fight back, but Blade gets surprise help.