Determined to rescue his mentor, Van Hesling, from the clutches of a pack of Mandurago vampires, Blade tracks him to a local slum in the Philippines. He also remembers his difficult childhood and the time he met his undead mother.

Captured Blade is taken to the Existence research lab known as 'The Factory', in Cambodia, to be experimented on by Deacon Frost who divulges his own tragic personal history, twisted motives and awful ambitions. Makoto finds them.