Twenty years after a mysterious death rocks Wallace University, another murder takes place.

When anti-Kappa Dean Cathy Munsch decrees that sorority pledging must be open to all students, and not just the school’s silver-spooned elite, all hell is about to break loose, as a devil-clad killer begins wreaking havoc across the campus.

In an attempt to protect herself from the killer, Chanel makes a surprising decision, which leaves Zayday in a position of power. To stay close to each other, the girls of Kappa Kappa Tau host a slumber party, but when a shocking discovery is made, not everyone will survive the night.

Dean Munsch is left in a desperate situation when a shocking event leads her to come face-to-face with her ex-husband's mistress. Meanwhile, in an attempt to determine who the Red Devil killer is, the Kappas use a Ouija board to communicate with Chanel #2 from beyond the grave and learn of a wicked plot against one of their own.

Denise does little to calm the Kappas' fears when she spins a terrifying ghost story. Meanwhile, Hester's shocking announcement pushes Chanel to the edge, and a familiar face returns to campus as the Red Devil claims another victim.

Shocking confessions are made as the Red Devil is finally unmasked and the killer revealed.

Shocking confessions are made as the Red Devil is finally unmasked and the killer revealed.

Years after the murderous events at Kappa House, Dean Munsch purchases an abandoned hospital under the guise of fixing the healthcare system in America. After recruiting surgeons, Dr. Brock Holt and Dr. Cassidy Cascade, as well as medical student Zayday Williams, the Dean shocks everyone when she enlists the services of the disgraced Chanels to join the ranks at the teaching hospital. Meanwhile, secrets from the hospital’s past begin to reveal themselves and a new killer surfaces.