In suburban Placentia, CA, the Jessee family does battle with cancer, never suspecting another killer lurks within their midst. With survivors pointing fingers at each other, police embark on an epic, decade-long murder investigation.

In the seaside town of Cary, NC, the Britt family lives a charmed existence until the housing market crashes, igniting a blaze of greed that will leave one family member dead and another behind bars.