In Tucson, AZ, the churchgoing Sanchez family of six seems perfect. But when the decomposed body of one member is found in the desert, investigators find a killer living very close to home.

In suburban Placentia, CA, the Jessee family does battle with cancer, never suspecting another killer lurks within their midst. With survivors pointing fingers at each other, police embark on an epic, decade-long murder investigation.

In Tampa, FL, multimillionaire lottery winner, Jeffrey Dampier, is sharing the wealth with his extended family. But lady luck can be fickle, and this family's red-hot winning streak is soon to end in cold-blooded murder.