In the two years following the death of Elizabeth Keen, Raymond Reddington and the members of the FBI Task Force have disbanded with Reddington's whereabouts unknown. When one of their own is injured in the line of duty, however, the Task Force is drawn back together to bring down a conspiracy that could shatter global security.

A kidnapping poses a test for the capabilities of the Task Force as they contend with a mysterious pirating organization.

A new case involving stolen artifacts reunites Red with a former blacklister. Aram faces a difficult decision.

The Task Force races to locate a blacklister who uses any means necessary to return what has been unjustly stolen. Ressler asks Park for a favor. Cooper tries to piece together an event for which he has no memory.

Dembe's position as an FBI agent causes complications for Red as the Task Force handles a case involving military technology. Cooper and Park each find their personal lives increasingly complicated.