When the gods capture Prometheus, mankind begins to lose the gifts he gave them: fire and the ability to heal themselves. It's up to Xena, Gabrielle, Hercules and Iolaus to try to free Prometheus from his chains but whoever is the one who frees him, may end up dead.

After Xena's death, Gabrielle becomes Queen of the Amazons, while Autolycus finds himself possessed by the warrior princess, Xena who needs ambrosia to bring herself back to life. But Xena's rebirth and Gabrielle's life are both threatened by an Amazon bent on obtaining the Amazon crown and the ambrosia.