England, 1868. A thief tries to raid an overturned carriage, but discovers that two of the occupants, a man and his young son are still alive. The man, George Joestar, proclaims he will forever be indebted to his savior, who reveals himself to be Dario Brando.

JoJo prepares to turn Dio in to the police.

The party are received by Doobie. Dire faces off against Dio. Straizo takes on Pajyu, Jones, Pluton, and Barnum.

In 1938, 49 years after Jonathan Joestar's death, Speedwagon and Straizo travel to Mexico, where they discover an underground room filled with similar looking masks and a petrified body believed to be the being who created them.

As expected, Straizo recovers from Joseph's attack and uses the laser eye attack Dio used to seemingly pierce through JoJo's head and neck. However, this turns out to be a clever trick by Joseph.

As Joseph begins to fight against Santana, Joseph finds his Ripple to not be effective against Santana, but it still helps protect him from the Pillar Man's attacks. Joseph appears to be unconscious after receiving a powerful hit.

Caesar engages Wamuu in battle for killing Mark, using his Bubble Launcher technique to surround the Pillar Man in Ripple enfused bubbles.

Wanting to teach JoJo to control his Ripple powers, Caesar takes him to Venice to meet his teacher, Lisa Lisa.

As JoJo awaits to warn Lisa Lisa about the Pillar Men, Esidisi's brain takes over the body of Suzi Q and sends the Super Aja off on a boat bound for Venice before confronting Lisa Lisa.

Lisa Lisa tells JoJo of Caesar's childhood, in which he took to crime at a young age after being abandoned by his debt-ridden father, Mario.

Launching his Final Mode attack, Gathering Gale, which starts peeling away his own body, Wamuu begins firing a stream of wind capable of cutting stone towards JoJo.

Kars demonstrates his new powers, turning his hand into a flesh-eating squirrel that deals damage to Stroheim. The sun rises, leaving a shocking discovery.

Jotaro heads to school and encounters a mysterious transfer student named Noriaki Kakyoin.

A giant ship shows itself. On board, they realize they can't seem to find a crew, but an orangutan.

Arrived in Singapore, Jotaro's group stays at a hotel individually. A new Stand owner who is known as "Devo the Cursed" is awaiting Polnareff in his room. Devo's Stand increases its power as its user's hatred towards the opponent increases. Polnareff gets into a desperate situation as he starts fighting front. Does Polnareff have a chance to win the battle against Devo who keeps attacking him in a cruel and brutal way?

After surviving Enyaba's attack, Jotaro and crew make it to Pakistan's capital, Karachi. There, they encounter DIO's next assassin, Steely Dan. Following DIO's orders, Steely Dan ruthlessly kills Enyaba in front of them. Jotaro and the others can't help but feel conflicted about that happening, and end up in a battle with Steely Dan.