Homer's rush to the hospital to reattach his thumb, Lisa's rush to school to win the science fair, and Bart's run-in with an illegal fireworks scheme are interconnected in a parody of Go and Run Lola Run.

Lisa tries to fit in with two college students by lying about her age. She finds that the college atmosphere is perfect for her, but her lie is soon discovered and she is shunned by her fellow elementary school students. Meanwhile, Bart is diagnosed with a weakened immune system after getting bitten by a Chinese mosquito and must live in a plastic, germ-free bubble.