As Dana's upcoming birthday makes her decide to seek a volunteer sperm donor so that she can have a child, she is confronted with a newborn who is HIV-positive. Lu is accused by an enraged mother of being responsible for her teenage daughter's sexually-transmitted disease because Lu provided the girl with birth control.

It's Andy Campbell's official first day as co-head of the Rittenhouse Women's Health Clinic. But before she can go in and save lives, she needs to help her two young daughters adapt to their new lives. Once she arrives at the hospital, Andy is left scratching her head, wondering what could be causing a woman's repeated miscarriages. Later, Lu and Andy face off when a drug-addicted patient almost dies from an overdose.

Trouble hits home when Andy suspects that her daughter has an eating disorder. On the job, the doctor doubts herself when confronted with the mysterious deaths of three of her patients. Meanwhile, Lu acts quickly to stop a possible outbreak of varicella, aka chicken pox.

Andy is forced to confront her father after discovering that he has a degenerative nerve condition that could threaten his independence; Lu treats a pregnant woman whom she subsequently discovers is under investigation in connection with several unexplained infant deaths.

Dr. Campbell's husband hits her and she kicks him out of their house.

Andy Campbell's kids miss their dad and want to know when he is coming home. Dr. Campbell has a hard time telling the kids why there dad moved out. Les Campbell has a hard time watching his temper. Andy isn't sure Jesse & Lizzy should know.

Academy Award-winning actress Rita Moreno guest stars in this episode of ""Strong Medicine,"" airing March 9, 2003 on LIFETIME Television. Moreno plays a street doctor treating patients who don't have the financial means to obtain medical treatment. Dr. Delgado makes a point of checking on her when she suspects the doctor may be growing senile. Later, Lu becomes frantic when she learns that a building has collapsed and her fire fighting boyfriend is unaccounted for while Andy counsels parents who are forced to make an extremely difficult medical decision about which of their two children should have lifesaving surgery

Andy helps Jesse cope having back surgery and trying to set things right between her husband. Lu tries to figure out how to spend time with Mickey and Marc. Lu wonders if Mickey would like to live with her.

Andy is worried about whether she should help in her daughter's surgery. Dr. Jackson deals with death of a young girl 6 years ago.

In a surprise twist following the suspenseful season finale cliffhanger, Mickey jumped in front of Lu and took the bullet for her; saving her life. Lu quickly rushes him to the hospital but little can be done to save his life besides putting him on a respiratory machine. Andy and Bob try to convince Lu to take him off the respirator. While Lu deals with the emotional trauma of Mickey's death, Andy tries to perform an experimental procedure on a baby in a bubble but is interrupted by Bob with news that the FDA has un-approved the procedure. Meanwhile Andy gets herself into a bureaucritical battle when she tries to get a patient who has no health insurance a free heart transplant. Also, Andy must tell Lizzy and Jesse that she and Les are getting a divorce and that he is moving across the country.

Lu fears that a little girl who keeps getting injured might be being physically abused by her dad. Andy suspects her nanny is stealing valuables from the house. Peter gets through to an insensitive husband of a pregnant woman about the pains of carrying a baby.

Lu faces an ethical dilemma about her doctor/patient confidentiality when an abused, pregnant woman appears to be missing. Andy confronts a doctor whose chauvinism may have cost a patient her life.

As a heat wave hits Philadelphia, Andy & the staff will need to get used to its disaster plan to cope with heat wave. Claire a patient of Dr. Campbell is told she will develop Alzheimer's disease within 10 years, she also wants to have a baby.

Andy & tells her kids about Dr. Morton, her kids question why she can't make time for kids. Clare worries that her kids might have the gene PGD (the gene that leads to finding Alzheimer's early.)

A young girl with Down's Syndrome tells Lu she shot a girl to get in a gang. The mother later tells Lu that she had her 16 year old (with Downs Syndrome) confess to the crime to protect her sister who actually committed the crime.

When a patient of Andy's takes a turn for the worse under Lu's watchful eye, the two doctors butt heads over whether proper procedure was followed. Meanwhile, Andy questions whether or not she can trust her oldest daughter. Also, when Andy and Morton try an experimental xenotransplant (using the heart of a chimpanzee), Peter questions the rights of the animal.

After Andy saves the life of a gunshot-wound victim, she and Robert must decide whether to accept a donation to the health center from the patient's less-than-reputable father. Meanwhile, Lu helps a breast cancer survivor to overcome her fears about body image and dating after a mastectomy. Also, while planning Jesse's Sweet Sixteen birthday party, Andy must come to grips with the impending financial limitations that her divorce will place on her family. When one of Andy's patients suffers from a heart attack, she and Lu disagree about the cause.

Lu treats a patient who may SARS the doctors tell patents about SRS as they wait for the lab tests. Ben comforts a patient. Andy worries that she will lose Jesse if she moves to California.

Andy tells a famous rock star and a patient to rest and cancel some of her concerts because of fatigue. The rock star invites Lu's young patient who has a terminal disease to spend the day with her. Lu's patient's mother directs a terrible accusation at the rock star. Ben starts a concierge service to keep the clinic open after it faces financial difficulties.

Andy is surprised when ex-husband Les shows up unexpectedly after Lizzy has her knee operated on after a soccer accident. Les learns that his wife is dating Milo. Andy invites Milo to dinner to meet Les and is shocked by the tragedy that ensues. Andy meanwhile treats a prominent judge for hearing loss and has trouble figuring out the cause of it.

Lana bets her pink feather pen that she'll sign up more people than a friend will for the Rittenhouse Breast Cancer Walk. She faces some difficulties, however, and goes to extreme measures to get people to sign up. Lu tells a teenaged patient that she is pregnant and she in turn tells Lu that Lu's son Marc is the father. In a shocking ending, the girl reveals a horrifying secret. Andy, meanwhile, takes action when Lizzy's friends receive ""fat letters"" and instead makes the school food healthier when Lizzy starts to severely diet.

Lu and Andy treat 3 patients that have similar symptoms but seem to have nothing in common. Meanwhile, Andy must meet face-to-face with the drunk driver who killed Milo. Andy is horrified when Jesse befriends him after he gives a speech about the dangers of drunk driving at her school. Meanwhile, Jonas is investigated for insider trading. Later, in a shocking climax, Jesse is in a drunk driving accident.

With Christmas only a few days away, Lana goes on a frenzy decorating the clinic and organizing a Secret Santa gift exchange. However, when a plan to set up Peter and Kayla backfires, she has a lot of explaining to do. Meanwhile, Lu delivers a virgin surrogate mother's baby but when the parents find out something about the baby, they do the unthinkable. Also, Andy must find a young girl who may die if she doesn't get treated for a deadly disease she may have.

Andy treats a beauty pageant finalist and finds that she has a shocking disease caused in part by her breast implants that requires surgery. Also, Andy tries to find time to talk to her friend, a presidential aide who is visiting from Washington D.C. Meanwhile, Lu deals with the pain and struggling of immigrants when a truckload of them show up on her block and is shocked to learn that all twenty of them are pregnant. Jonas invites Lu to dinner with his extended family and Lu gets a toxic surprise. Later, Lu has difficulty finding a fuel-efficient car and a lost box could ruin her relationship with Jonas' family. Finally, Peter and Kayla try to work through the red tape of workplace romance and start a relationship.

Andy must face the questions of people opposed to her becoming Surgeon General while she struggles to get Senate confirmation. Lu's unique way of practicing medicine and their relationship challenge her chances. Kayla and Peter prepare for the next step in their relationship but struggle to find privacy. Lu reads something in a newspaper about Jonas that could change their relationship forever.