Becker reluctantly agrees to shuttle Reggie, Margaret, Jake and Linda to various engagements in Queens when they learn that he's heading that way in his car. It quickly becomes a "what-was-I-thinking" scenario for the gang when Becker's terroristic skills behind the wheel cause an accident. Even More Shameless Crossover Monday winds up when Dr. Becker returns to his office waiting room to find Hilton Lucas, Doug Heffernan and Ray Barone -- side-by-side -- waiting.

Before leaving for a medical conference in Chicago, at which he is scheduled to speak, Becker discovers that he has an extra airline ticket, which Reggie ends up using. Once aboard the plane, Reggie is immediately annoyed by the flight attendant and fellow passengers while Becker is uncharacteristically taking it all in stride. When Reggie discovers that Becker is high on Valium, she's alone in her misery until bad weather causes a delay and finds them stuck for hours on a tarmac in Buffalo. As the Valium wears off, Becker's temper and tongue-lashings return and the situation becomes a pressure-cooker about to explode.

Reggie's celebration after earning an A in her psychology class turns to panic when she considers her uncertain future; and John entertains one of his neighbors, who turns out to be a hooker.

Becker's office is vandalized, and many, many people appear to have a plausible motive. It turns out that it was just Linda throwing a party, but she goes on a date with the clueless cop assigned to the case to keep him quiet. Meanwhile, Bob has been hanging out in Becker's apartment during the day and impersonating the doctor.

John hurts his shoulder and is afraid to have an MRI, so Reggie goes with him for support; Linda dates identical twins.

John gets jealous and lies to a friend who expresses interest in Chris by telling him that she is gay. Unfortunately, the man acts on John's information and sets Chris up with a lesbian acquaintance. Also, Bob tries to deepen his friendship with Jake and buys a pair of walkie-talkies so that the two of them can stay in constant contact with each other.

Chris tries to get John to be more considerate of her feelings, but he's not sure he can do it; Hector tricks Jake into selling porn magazines; Margaret takes a night job with a telemarketer and is shocked when she learns that it's a phone-sex operation.