New York City firefighter, Tommy Gavin, cannot escape the ghosts of those who have died around him as he faces the everyday challenge of saving lives while trying to fix his own.

When a retired gay firefighter makes a published claim that several firemen who died in 9/11 were closeted gays, Chief Reilly is determined to set the record straight. While attempting to mask the pain of losing his wife and kids, Tommy does Jimmy a favor and spies on his widow which leads to a surprising discovery. The probie must deal with the unexpected repercussions of being a hero after making his first save in a fire.

A "friendly" date between Tommy and the widow of his dead cousin takes a unexpected turn when she makes a move on Tommy. Franco's ex-girlfriend shows up at the firehouse and claims he's the father of her five-year-old daughter, turning his life upside down.

Tommy comes to terms with the reality of his broken family as a result of a shocking experience with his father. When a freak accident occurs, Franco must make a life-changing decision, and Chief Reilly is forced to expose a family secret in order to save his career.

When Tommy discovers a secret that Janet is keeping from him, he must come to terms with the possible consequences. At the firehouse, Chief Reilly preps the boys for their new female replacement. With the help of Franco and Sean, Tommy tracks down the man responsible for Billy's death.

When Tommy struggles to help Janet in a financial crunch, he must turn to his Uncle Teddy to help him out. The new female addition to the house fights to be accepted by the guys while they do everything they can to drive her nuts. Just as Mike is getting fed up from sleeping on the firehouse couch, he is offered a helping hand with a free place to stay... at a steep price.

In the opener to the second season, troubled Tommy Gavin is having a difficult time adjusting to life at his new uneventful firehouse after the volatile split with his old crew. On top of this he is still looking for his missing wife who has kidnapped his three children and he has to come to terms with the fact that his dead cousin’s wife is pregnant with his baby. His frustrations come to a head and he has a meltdown with a street vendor selling 9/11 memorabilia.

In an effort to get more time off to search for his wife and kids, Tommy joins the new firehouse’s Barbershop Quartet. Meanwhile back at the old station, Lou and Chief Reilly conspire to get Tommy back, but the rest of the crew has grown fond of his replacement.

Tommy asks his cousin for help in understanding the bizarre visions he's been having. The crew tries to help Laura understand the essence of male comaraderie.

Franco's addiction to painkillers has driven him to a support group to get help with his problem. A young boy clings to life after Tommy saves him from a fire. Jerry is introduced to his gay son's life partner.

Tommy starts taking Janet's antidepressants. When Sean meddles in Franco and Laura's troubled relationship he makes things worse. After a gay visitor, the crew wonders about Mike's sexuality.

When Tommy, Johnny, and Mickey confront Father Murphy it results in tragedy. Sheila needs Tommy's help with a domestic issue. Jerry decides it's time to get a nurse to care for Jeanie. Lou offers to help Candy out with her situation. And Laura discovers the truth behind Franco's poetry.

Tommy lays off the antidepressants when he is kicked off the hockey team. Sheila asks Tommy to talk Damien out of being a firefighter. Meanwhile, when Franco sees Laura with another guy he gets jealous and Tommy's dad gets a surprise when he returns home from a three day trip to Atlantic City.

Tommy copes with a tragedy. Jerry must decide what to do when his wife's condition worsens. Sean has a crisis of faith. Lou learns some shocking facts about Candy. And the crew responds to a multi-level building fire with people trapped inside.

During a night out, Franco and Tommy meet two women. Tommy is finding himself bribing his daughter Colleen before she tells their mother about his indulgent treatment of her sister Katy. Jerry visits his wife Jeannie in her expensive nursing home and soon goes to Lou for financial help. Meanwhile John Sr. insists on having his 83rd birthday at a restaurant that no one else likes.

After Sheila bumps into Johnny's ex-wife, Angie, Tommy seeks her out. Jerry and Rose spend a very romantic evening together, while Mrs. Turbody is in jail for statutory rape. This gives Tommy some relief but also new worries, and Franco loses his daughter, Keela.

Sheila lies to Tommy when he confronts her about the beach-house fire. But they present a united front to the insurance investigators, as embarrassing as it is for Tommy. Meanwhile, Lou is determined to get a basketball ringer (Larenz Tate) to be 62 Truck's new probie; Uncle Teddy is released from jail; Colleen runs away with her rock-musician boyfriend; and Mike's mother has a deathbed request.

A devastating fire has a profound effect on the crew; Tommy wrestles with his feelings about the baby; Alicia (Susan Sarandon) returns with a proposition for Franco; Troy breaks up with Sheila while Lou makes a tough decision about Theresa; and Sean apologizes to Mike about the fire he set that burned down Mike's mother's house.

With Damian confined to a chair and a new baby on the way, Sheila and Janet join forces and shake-up Tommy’s family life.