Ryan forms a unique connection with his neighbor's dog after a failed suicide attempt.

Wilfred is angry after Ryan tricks him into going to the veterinarian.

Ryan gets his wallet back (that's the good news) when his malevolent, porn-addicted neighbor Spencer shows up. The bad news? Spencer's looking for answers about who broke into his house. He's also looking for blood.

Ryan tries to reconcile with his sister, and Wilfred is in for a shock at doggy day care as a result.

Wilfred reveals an extraordinary ability when Ryan takes him to a hospice to volunteer.

Wilfred persuades Ryan to help him get rid of Jenna’s boyfriend.

Ryan must swallow his pride when Wilfred pursues a new love interest., and Ryan meets a new romantic interest himself

Ryan has a guilt complex over the death of his childhood dog, and Wilfred, upon learning of it, goes to otherworldly lengths to help Ryan discover the truth about how the pooch passed on. Meanwhile, Kristen throws a party for her boss.

Ryan's resentment of his mother even grows when she moves in and becomes friends with Wilfred.

Wilfred tries to find Ryan a human friend.

Ryan meets someone who questions Ryan's friendship to Wilfred.

Just as Ryan finds happiness in his life, Wilfred begs him to sacrifice it for a larger purpose.

A crisis arises when Ryan ignores Wilfred's advice.

Ryan learns that life is much more challenging without Wilfred around.

When Wilfred comes to the conclusion Ryan is the only beneficiary of their friendship, he denies Ryan any further help.

Ryan has to deal with new problems when Wilfred becomes popular.

Ryan is forced to intervene when Wilfred becomes embattled with an unlikely foe.

Unexpected problems arise for Ryan and Wilfred after a traumatic experience.

Wilfred muddles Ryan's plan to introduce Amanda to Jenna.

A hairy situation puts Wilfred and Ryan's friendship in jeopardy.

Wilfred's nemesis returns with an offer that rocks Ryan's world.

A spontaneous road trip proves disastrous for Wilfred and Ryan.

Ryan and Wilfred make an extraordinary effort to boost Jenna's career.

Ryan attempts to discover the truth about Wilfred through self-examination.

Wilfred derails Jenna and Drew's wedding because of Ryan's jealousy.

In the second-season finale, existential questions are posed to Wilfred and Ryan.

Ryan and Wilfred search for Wilfred’s original owner.

Ryan befriends Wilfred’s enemy—the mailman.

Ryan distrusts his sister's new love interest.

Ryan takes Wilfred to a dog training class in the hopes of winning over a girl.

Ryan finds a roommate with Wilfred's help.

Wilfred forces Ryan to collaborate on a birthday gift for Jenna.

Wilfred leads Ryan on a crime-fighting caper.

Ryan tries progressive psychotherapy to better understand a past trauma.

Wilfred crashes Christmas and pits Ryan against his family.

A struggle emerges between Ryan, Wilfred and an old friend.

Wilfred pursues a forbidden love.

Ryan is put in danger as Wilfred pursues the path to valor.

Season 3 ends with Jenna forbidding Ryan from seeing Wilfred when he needs him most.