Danny tries to find the source of a deadly narcotic after three teenagers die from an overdose.

A high-end escort's body is found in the river; Frank vows to get justice in a 25-year-old case.

Just before Danny is to give witness testimony at a Peruvian drug lord's murder trial, Linda is kidnapped. This drug lord has a history of intimidating witnesses.

Erin has to re-open a 18yr old rape case in which Frank was the arresting officer. Danny and Jackie have to deal with the murder of three teenagers for which there appears to be no motive.

When a man’s family is robbed and beaten in front of him, and the assailant is shot and killed, the Reagan’s debate about how far they would go to protect their family. Meanwhile, when a college student is arrested at a rally, Frank wrestles with her sentence due to her identity.

Danny causes waves in the department when he investigates a closed case, the suicide of a firefighter, at the insistence of the man’s 12-year-old son. Meanwhile, Jamie saves a baby from a burning building but worries it will jeopardize his undercover work when he is billed a hero in the press.

Danny believes a serial killer is on the loose when two separate murder victims are identified as members of a group charged with a gang rape. Meanwhile, Erin’s ex-husband, attorney Jack Boyle, resurfaces in her life as they face off in court.

When Danny and Kate come up empty-handed with leads for a shooting, Linda helps make a break in the case when she overhears the victim telling his priest who is responsible. Meanwhile, Henry is mugged at an ATM, which sends Jamie into a rage as he tries to track down the assailant.

When a 10-year-old boy is the victim of an incident in the projects, Danny’s heated approach to the case lands him in anger management class. Meanwhile, Frank navigates the politics of the State Department and the Turkish Government in order to help a young Turkish woman avoid persecution.

When Danny finds a disoriented man in a park covered in his girlfriend’s blood, he finds it hard to believe that the man has no recollection of the night’s events until they find a strong narcotic in his bloodstream. Meanwhile, Jamie gets into trouble when he helps an off-duty officer cover up his intoxication after he apprehended an armed robber.

Danny becomes the lead hostage negotiator when a prime informant in a large drug case holds Erin at gunpoint inside the courtroom.

Frank is put in danger when his dinner companion, mob lawyer Angelo Gallo, is shot; Danny is a juror in a murder trial.

Danny and Baez search for a Marine veteran who may have PTSD; a woman seeking justice for her murdered daughter catches Frank off-guard during a press conference.

A woman dies after undergoing a secret plastic surgery, so Danny and Baez try to figure out what happened. Elsewhere, Frank asks Jamie to solve a cold case; and Erin explores the world of speed dating.

Danny tries tracking down the drug cartel who's attacked a convoy of drugs been transported to be incinerated. Baez is left injured. Frank treads carefully.

An interview goes badly for Frank after he ends up being blindsided by the interim district attorney. Danny and his new boss deal with a drive-by shooting.

Evidence against Danny surfaces when the attorney general's office reviews his shooting of a serial killer. Jamie and Eddie deal with a high-profile drunken driver. A slain cop's widow asks Frank for a favor.

When a key witness in Danny's case is killed just before testifying, Erin angers Danny by enlisting Anthony (Steve Schrippa) to help him find the killer. Also, Robert Lewis (Michael Imperioli) tries to force Frank to publicly support the Attorney General's investigation of the use of excessive force by police, and Eddie and Jamie get the call for an attempted suicide.

When diplomatic immunity complicates a child abuse case for Danny and Baez, Frank intervenes, despite not having jurisdiction on the case. Also, a robbery occurs while Eddie and Jamie are on a double date with Eddie's boyfriend and his sister, and they are forced to step in.

Erin faces off against her ex-husband in court when he represents the person she is attempting to convict of murder. Frank is confronted by a mother who accuses the NYPD of being negligent in solving her son’s murder. Jamie rides with a new partner.

Danny considers retiring until Erin asks for his help with a case involving her ex-husband; Jamie and Eddie pose as a couple; Frank clashes with the new mayor.

A case turns personal for Danny when he works to protect a nurse, Faith Madson, from her violent ex-boyfriend. Also, Shelly Wayne, an acquaintance of Frank's, comes to him with a theory regarding the death of an inmate, and Jamie and Eddie help deliver a baby.

When Henry is the key witness on Danny and Baez's case, his meddling pushes Danny's buttons until he leads them to valuable information. Also, Nicky shocks her family by siding with her activist friend, Chrissie, who defaced the NYPD flag at One Police Plaza, and Jamie and Eddie learn a parole officer is taking advantage of his power over parolees.

After a woman voices her outrage regarding the NYPD’s inability to find her son’s murderer, Danny reexamines the case, upsetting the original detective, Erin, and Anthony, who didn’t pursue the case due to lack of evidence. Also, Eddie is shot while on duty; Erin and her ex-husband, Jack, face off in court; and Frank contends with an angry police force when Mayor Dutton fails to defend them at a press conference.

Danny takes on a personal case involving a drug cartel member who Danny believes is responsible for torching his house. Erin is given a promotion in the DA's office but finds herself in a challenging situation when both Danny and Jamie ask her for help with their investigations. Frank and Jaime have a disagreement when Jamie refuses to stop riding with Eddie.

Things get personal for Danny when the drug cartel hit man responsible for torching his house resurfaces. An attack on an officer in the line of duty directly impacts a member of Frank's team. Eddie reluctantly introduces Jamie to her mother.

Erin and Frank clash over new legislation from the district attorney's office that undermines Frank's policies. Erin is at odds with Governor Mendez over questionable sex-trafficking laws. Danny risks his badge to protect a friend from losing his.

A medium approaches Danny and Baez claiming to know what happened to a woman who was found dead of an apparent suicide. Also, Jamie and Eddie help a woman who bought cheap insulin online that nearly killed her son; Frank goes against the wishes of the archbishop to take down a man he believes is laundering money from a charity; and Erin’s ex-husband asks her for help with an assault and robbery case.

After someone breaks into Luis Delgado’s home and kills his wife, Luis and Danny team up to take down the vicious murderer who may also be responsible for Linda’s death. Also, Frank finally meets Eddie’s mother, Lena, and Jamie and Erin are at odds after Jamie seeks her help charging a man who confessed to him while under the influence.

Danny and Baez grapple with a homicide investigation brought to their attention by Maggie, the medium who previously helped them solve a case; Frank looks for a way to help his ex-partner Lenny Ross when Lenny's daughter gets arrested.

Jamie and Frank oppose each other's viewpoints over the public's treatment of cops after rowdy teens pour water on two rookies. Danny and Baez investigate a man who preys on the elderly. Erin is forced to admit her wrongdoings.

A widow blames Frank for her husband's recent suicide; Eddie has a gut feeling about a murder; a desperate Luis Delgado wants protection for his sons.

After getting a match from an unknown relative from a DNA network, Sean Reagan does some detective work to figure out who this mystery person might be. Frank gets a personal request from a woman to transfer her son to a safer assignment. Also, Danny seeks to uncover the truth behind the murder of a key witness in one of Erin's cases, and Eddie begins to think about having a child after she and Jamie discover a newborn left outside their precinct.

Amidst a shifting political climate, Frank goes head to head with City Council Speaker Regina over protests against police brutality. Also, Jamie and his nephew Joe Hill work together to locate Danny and Baez when they go missing while searching for a killer, and Eddie steps up to help an abrasive woman find her father's body after it was misplaced during the outset of the pandemic.

Erin tries not to feel overpowered as her new boss shadows her at work just as she's trying to get a nervous eye-witness to reveal the identity of who shot her boyfriend. Also, the serial killer who previously held Danny and Baez hostage resurfaces, and when Jaime arrests an intrusive reporter who appears at a series of store lootings, it leads to a standoff between Frank and the Attorney General over the press' First Amendment rights.

Business becomes personal for Frank and his 1 Police Plaza team when Baker is assaulted on the street, as well as for Erin, when she asks her ex-husband, Jack Boyle, to represent a defendant she’s prosecuting. Also, Eddie wonders if she’s being too stubborn after she publicly undermines one of Jamie’s decisions at work, and Danny and Baez investigate the attempted murder of a couple with huge secrets.

Shockwaves ripple through the Reagan family when Danny discovers that their newest family member, Joe Hill (Will Hochman), is working undercover for the ATF to bring down a gunrunning organization.

The Reagans band together to prevent Joe Hill from being killed in the line of duty like his father when they fear Joe’s cover has been blown within the gunrunning outfit he’s helping the ATF bring down.

Frank causes family tension when he assigns Jamie to guard Danny after a hit is put on him; Frank tries to stop his grandson from seeking revenge after he’s attacked; Eddie gets a hostile new partner.

Frank is at odds with his friend Archbishop Kearns when he says the NYPD arrested the wrong man for a murder; Eddie tries to get justice for a sexual assault survivor; Jamie and his nephew, Joe Hill, butt heads over fair police practices.

Jamie and Joe search for an undocumented teenage girl who has been sex-trafficked; a woman in witness protection is murdered; Frank calls out the district attorney's office for instituting a new rule that classifies armed robbery as a misdemeanor.

Eddie and Jamie deal with a domestic violence case associated with an investigation lead by Danny and Baez; Frank and his friend go on a mission to avail themselves to an unfiltered look at the city; Erin is presented with a surprising offer.

Erin and Anthony clash when Anthony's daughter is the sole eyewitness to a fatal shooting; Frank wants to punish an off-duty cop for his inaction during an armed robbery; Danny and Baez investigate a violent mugging.

Danny and Baez race against the clock to catch a serial killer targeting young women; Erin and Eddie clash when Eddie intervenes in a murder case and Erin's personal life; Frank must decide how to discipline his grandson.

Danny and Baez team up with Danny's old partner to find a copycat killer emulating a criminal's murders from a previous case; Frank and Mayor Chase battle over how best to handle the city's rising homeless population.