The team investigates the abduction of a young woman and her daughter, who are being held prisoner by somebody who wishes the team to release a prisoner arrested on a murder charge a year ago. At the same time, Sam faces a life or death situation in 2006 when he thinks he has accidentally been given an overdose. As the deadline draws closer, Sam collapses into a deeper coma, leaving his colleagues to tackle the mystery on their own (Albeit using some of his earlier suggestions).

As heroin hits the streets of Manchester for the first time, CID and DCI Hunt want culprits for the smuggling, the dealing and ensuing violence, which becomes difficult when Annie is kidnapped by the smugglers. As Sam tries to get to the source of the influx of this deadly drug, he finds himself intractably drawn to a beautiful young woman who was witness to a heroin-related shooting... and who, he later realises, is the mother of his girlfriend in the future. At the same time, Sam's 'visions' reveal that his girlfriend has decided to stop visiting him in hospital, as she can't keep waiting for him to wake up.