Leonardo apprentices as an artist and craftsman in Florence, where the Renaissance is in full bloom. He shows extraordinary talent but struggles to finish commissions. Later, in Milan, he paints a monumental fresco of the Last Supper.

Leonardo designs fanciful flying machines, studies light and shadow, investigates gravity, dissects cadavers, and pours the sum of his scientific and artistic knowledge into a portrait that would become the most famous painting on earth.