Dr. Lanning and Dr. Keating team up to save a newborn baby in distress. Meanwhile, Dr. Keating must grapple with a medical scare that could affect her own ability to have children. Dr. Brennan returns from her yearly foreign medical mission, known as ""Doctors Without Borders,"" where she has been having an affair with a Greek physician. Upon her return, she must help a man deal with the impending death of his father, who has cancer. Dr. Slingerland enlists Dr. Jordan to help him convince a zealous high school football coach of his urgent need for heart surgery. At the same time, Dr. Colette brazenly begins her new job by bullying an HMO to approve surgery for an elderly woman.

Dr. Jackie Collette struggles with her reluctance to treating burn victims when a critically burned firefighter needs her help. Meanwhile, Dr. Brennan refocuses on making her marriage work and attempts to make it easier by asking Dr. Kokoris to leave Presidio Med and return to Greece.

Drs. Slingerland and Jordan diagnosis a cable car worker with Carpal Tunnel Syndrome and a heart problem, Dr. Keating looks for doctors who willfertilize her eggs, and Dr. Colette learns that the fire fighter she treated for burns is in love with her!

Dr.Kokoris operates on another patient; A fitness instructor complains of muscle problems and learns he has something different.

Rae splits up from her husband Sean while helping a 9-year battle Leukemia.