Three test subjects of an elaborate experiment start experiencing strange symptoms and turn to geneticist Dr. Alex Sarkov for help.

In hopes of finding Sarkov, the Imperfects look for another Wellness Program participant while dealing with the fallout from their new powers.

After receiving bad news from home, Abbi attempts to replicate the cure. Juan attends a party. Tilda tries to warn Sarkov of the risks of using nanobots.

Abbi and Tilda band together with an unexpected ally to go after Sarkov, who has big plans for Juan. New revelations bring new challenges for the group.