Legendary frontiersman Daniel Boone faces the biggest challenge of his life when the Shawnee take him as their prisoner. If he can't escape, he won't be able to warn the settlement of Boonesborough, and his family, of a looming attack.

When frontiersman James Harrod founds Harrod's Town on Native American hunting grounds, he soon finds his new settlement under attack. His leadership is tested as he defends the first European settlement west of the Appalachian Mountains.

After successfully mapping the rugged Ohio Country, frontiersman and surveyor Christopher Gist is hired to lead a young George Washington on a perilous diplomatic journey to deliver an ultimatum to the French forces in the Ohio wilderness.

When Chief Pontiac organizes a coalition of Native American tribes to attack British forts, frontier trader George Croghan risks his life on a perilous journey into the wilderness to find Pontiac and attempt to negotiate a peace agreement.