Following a chain of unexpected events, our Heroes are on the run from their latest adversary and one of their own, Nathan Petrelli. After Matt paints a series of prophetic images, the tragic fate of someone close to him is revealed. Elsewhere, Sylar continues his search for his father and encounters a young outcast with information and an ability of his own.

Nathan's plans face exposure as Homeland Security begins an investigation under direct orders from the President of the United States. Sylar and Luke embark on a road trip to find Sylar's father, but are secretly being hunted by Nathan's agents. Life gets complicated for the Bennet family as Claire goes into action to protect a young man with abilities from being captured by HRG. Elsewhere, Matt's prophetic images lead Hiro and Ando to India and a mysterious ally comes to the aid of our Heroes

After receiving a tip from "Rebel", Matt and Peter race to Building 26 to rescue Daphne and recover files that will expose the government's plans for those with abilities. Claire finds help from an unlikely source in smuggling Alex out of the city. As Sylar and Luke continue their road trip, Sylar begins to have memories of his father that lead him to the truth about his mother. Meanwhile, "The Hunter" puts his own agenda into action with an explosive surprise for one of our heroes.