In an effort to keep his finger on the pulse of Metro City, Megamind goes undercover as an ordinary sales clerk but soon learns there have been a series of robberies and disappearances in the store.

Megamind, Chum and the rest of the team attempt to infiltrate a festival thrown by Machiavillain to expose him as a villain to the rest of the city.

After Machiavillain mind-controls the citizens of Metro City, it's up to Megamind and Keiko to find a way to cure them all.