Chum clones himself to get everything accomplished and take care of an ill Megamind; when the clone makes additional copies of himself, things get out of hand.

Megamind's confidence is tested when Machiavillain finally reveals himself to the blue hero and puts him through a series of challenges to save the city from destruction.

Machiavillain traps Megamind in a simulation designed to turn him evil again.

Megamind swaps powers with Metro Man while fighting a new villain known as Destruction Worker.