Megamind tries to win over the citizens of Metro City but finds his popularity tested by a new hero.

Roxanne's rekindled friendship with an old camp buddy makes Megamind jealous, so he reprograms Keiko's robot science project to act as his new best friend.

With Metro City once again thinking that Megamind is a villain, he must make his way through town without being spotted. Things become complicated when a plucky 7-year-old boy thinks he's the hero who can stop Megamind.

Megamind runs into his former nemesis Metro Man while trying to escape prison.

Megamind faces the ultimate challenge when he must square off against a mind-controlled Roxanne.