Jane Halifax, forensic psychiatrist, facing a gruelling cross-examination at a murder trial, is contacted by ex-boyfriend, Owen Tozer, ( Andrew McFarlane ), also a psychiatrist. He has been having an affair with a patient, Cori Neal ( Sophie Lee ) and seeks Jane's assistance. Owen's own mental state takes a downward spiral when a pregnant Cori is murdered in a hit-and-run accident. To make matters worse, the car involved belongs to Owen. With the police hunting Owen as their prime suspect, Jane is torn between working within the law and helping her ex.

While assessing a convicted murderer for the Parole Board, Jane is asked to provide Grief Counseling at an exclusive boys' school where a teacher has suddenly died. When a pupil she is counseling is murdered, Jane works with local detective, Kaz, (John Walton), to uncover a secret society within the school controlled by a dangerous psychopath. As Jane gets closer to the murderer, her own life is in danger, as she unravels a web of deceit, conspiracy and murder.

Rogue cop, Jonah Cole, ( Steve Bisley ), from Sydney comes to town on the hunt for the 'Make-up Killer'. This is a high profile case where the police are under pressure from politicans and the media to get a result. Calling on Jane Halifax to provide a profile of the serial killer, Jane and Jonah initially lock horns in their attempt to catch the culprit. With his acute sense of smell, Jonah recognises a familiar scent that links all the victims. Abrasive and eccentric in his approach, Jonah's obsession to find the killer wins him no friends, but Jane proves to be equally skilled as his work-mate in this deadly and dangerous pursuit.

Jane finds her misquoted criticism of a colleague's release of a mental patient, who murders again, leads to a patient of her own, Peter Donaldson, ( Ben Mendelsohn ), facing the pressure of exposure to an unforgiving public. In an attempt to help him come to terms with the situation, Jane discovers someone who bears a grudge and is dangerously close to driving Peter over the edge.

Two cops, one young and idealistic, the other tough and cynical, are party to the shooting of a criminal. Called to assist the police in their internal investigations, Jane Halifax discovers all is not as it seems. Delving into the murky underworld of organised crime, bribes and corruption, Jane races against time to save innocent lives.

Jane is called on to assess wealthy socialite, Sharon Sinclair, charged with the murder of her father, Sir Edward and her step-mother. Sharon is suffering from Multiple Personality Disorder, but Jane discovers that Sharon's own psychiatrist is writing a book on the condition and may be biased. If found medically unfit to stand trial, Sharon stands to inherit eighty million dollars, so Jane is effectively advocate, judge and jury. Jane's attraction to Detective Paul Santos develops into a passionate involvement, but as a result of this distraction, she misses a vital clue. Blaming herself, she ends the relationship with Paul only to discover that her initial theory was correct. During her investigation, Jane discovers that there is more to Sharon Sinclair and her family than meets the eye.

Ex-cop, Laurie Downes has displayed erratic behaviour and has taken the law into his own hands. Having assessed him as safe to be released on bail, Jane discovers that his actions have a specific purpose. He is on the trail of two rapists who are responsible for the death of his lover. Jane has discovered that she needs surgery as the result of a Papp Smear where irregular cells have shown up. When one of the rapists is murdered, everything points to Laurie, but Jane finds that it is she who is the rapist's intended victim.

Jane rushes back from New Zealand where she has been lecturing, for the funeral of her best friend, Dr. Lisa Hardman. Staying to help Lisa's husband with the children and to wind up Lisa's psychiatric practice, she discovers a patient who displays a dangerous obsession with Lisa's family. Jane begins to suspect that Lisa's death was not due to natural causes and when first she, then Lisa's husband, get sick, Jane realises that she is dealing with a serial poisoner.

When gossip colominist for A-list magazine, Simon Laser, walks into a police station claiming that his murdered lover, prominent judge, Harvey Masters, died in his arms, he is treated with suspicion from the start. Not only was Masters seemingly happily married, he was also known for his strong conservative beliefs. Laser claims their affair was kept a secret and that the killer is out to avenge him by killing those closest to him. It is up to forensic psychiatrist Jane Halifax to determine if Laser is telling the truth, or if something more sinister is lurking under the surface.

Jane has been asked to assess a stalker and when she assures the judge that he is safe to be released, the husband of his victim is not pleased. When his wife is murdered and it is clear that the stalker is the murderer, Jane feels that she is to blame. However, when the Australian Secret Service (ASIO) are involved, there are more coincidences than a paranoiac can shake a stick at!!

On the tenth anniversary of her father's death, Jane is approached by an old friend of her father. She asks Jane to assess a thirteen year old girl accused of murdering an eight year old.

While Jane works on a fairly mundane case for the parole board; that of a girl accused of malicious damage to a neighbour's car; she begins an affair with a married police officer, Det. Brett Murray. The case he is working on involves a number of missing persons who turn up dead. Jane soon finds a link between the two, but when the cop offers to leave his wife, Jane's fear of commitment causes them to split up. As a result, Jane finds herself in extreme danger from a pair of mentally unstable and irrational girls.