House uncovers a startling secret when he treats a teenage supermodel for heroin addiction. Meanwhile, Wilson hopes the increased leg pain in House's leg is an indication his leg nerves are regenerating.

While Foreman takes on a pediatric case on his own, the rest of the team deals with a 16-year-old factory manager and emancipated minor who collapses at work. When Foreman's patient takes a turn for the worse, he's forced to question whether he can deal with the situation on his own, or if he needs House's help.