While tracking a young boy with dangerous powers, Dr. Helen Magnus encounters Will Zimmerman, a psychiatric resident who may have what it takes to become her new protégé.

Will Zimmerman is drawn further into Magnus' mysterious world and finds himself confronting his oldest fear. Elsewhere, forces converge on the target of their hunt - including someone from Magnus' distant past.

The origins of the mysterious mutant boy are revealed, as is the relationship between Magnus and her old flame, John Druitt. Meanwhile Ashley Magnus (Emilie Ullerup) seeks out Ernie Watts (Peter Deluise) a weapons dealer and fellow monster hunter - only to find herself in mortal danger.

Helen and Will confront John Druitt with deadly results for a member of the Sanctuary team. Ultimately, Will is forced to choose between his old life and the strange world of Dr. Helen Magnus.

While investigating an ancient crypt on a remote island, Magnus and her team encounter deadly creatures and three women with a mysterious past. Ashley decides to address the issues of her father's existence head-on.

Will falls victim to the three women's growing powers, while Magnus seeks proof of their true identities via a former resident of the Sanctuary. Ashley's luck in her monster hunt begins to run out.

Magnus, Will and Bigfoot defend the Sanctuary against a deadly assault, while Ashley struggles to survive her encounter with a nearly unbeatable foe.

The enigmatic Dr. Helen Magnus recruits insightful forensic psychiatrist Will Zimmerman to join her in the quest to track, study and protect the strange and often terrifying creatures that secretly populate our world.

As Will attempts to help Alexi cope with his abnormality, Helen gets a visitor from her past.

Dr. Helen Magnus, her daughter Ashley, and new to the Sanctuary, Dr. Will Zimmerman release three women from a mysterious crypt in Scotland, bringing them back to the Sanctuary for refuge. Unbeknown to the team, and the women themselves, they have extraordinary powers. And their disappearance does not go undetected by a powerful cabal, resolute on reclaiming what it determines is theirs.

After capturing a particularly elusive abnormal the plane carrying Dr. Magnus and Will crashes while transporting the creature. Dr. Magnus and Will soon discover why this abnormal has never been captured before.

While leading a covert meeting in Rome, Magnus encounters an old friend from her past who confides that the cabal has come to exact revenge on her for the events in "Fata Morgana."

Magnus and Will investigate a distressing call for help deep below the Bermuda Triangle resulting in a deadly battle to save Magnus’s life.

Magnus and the Sanctuary team attempt to capture a rare and deadly creature - all under the watchful eye of a local news crew.

Abnormals in remote regions are subjected to an airborne biological agent that compels them to launch a violent string of murders

The Five, led by Magnus, attempt to find the secret labyrinth in the decimated city of Bhalasaam. Once located, they must complete a series of cryptic tests that can only be achieved using each of their unique powers.

The search for Ashley puts Magnus and her allies in the path of Kate Freelander (Agam Darshi), a con artist with ties to the Cabal who divulges the location of a secret facility

The Cabal's new "Super-Abnormals" begin destroying Sanctuaries around the world. It won't be long before they launch their attack on the Old City Sanctuary, and Magnus must choose between saving Ashley and saving the Sanctuary Network.

A disoriented Magnus wakes up to find the Sanctuary in ruins and the entire city decimated, with no memory of how the devastation occurred. While surveying the destruction, she is attacked by an inhuman creature but saved by two armed men who stun her and take her to an abandoned warehouse. After being hosed down and left shivering and exhausted, Magnus fears the worst when a battle-scarred figure enters the room.

While transporting a usually docile abnormal, Magnus's helicopter crashes, leaving her and Will stranded in the shaft of an abandoned oil rig. They soon find they are not alone in the water.

The team rescues the occupants of a sinking ship off the coast of South Africa and teleport them to the Sanctuary. However, Magnus suspects Druitt of murdering one of the passengers during the rescue.

Will begins to experience strange visions that are connected to the Cult of Kali. Magnus has difficulty with finding the solution to their problems.

Will suffers from amnesia regarding the events of his near-death experience, but some unwanted visitors become intent on finding out what is locked in his memory.

Magnus responds to an anonymous call for help at an abandoned building. But when she gets trapped inside, she discovers whoever made the call has a very different agenda.

Magnus is revived to answer Ranna's questions and soon figures out that despite Ranna's efforts the city is in great deal of trouble and the fall of Praxis could also threaten the surface world however Magnus is able to help. Magnus and Ranna makes an understanding to help and she revives rest of the gang. Magnus manages to save the city with the help from Gregory Magnus meanwhile Will tries to breakdown Adam's plan that can cause huge trouble.

Looking to share a quiet, "normal" evening out with Abby, Will and his date are abducted en route to the restaurant by a desperate gang leader who faces certain death without their help. Then, upon learning the abductor's identity, Magnus suddenly ceases all attempts at rescue.

Discover Magnus' role in a turning point of World War II history.

Helen and Will find themselves in an alternate reality, living as suburban neighbors, who experience unsettling dreams that disrupt their new careers.

Magnus has pursued Adam Worth back to 1898 London to stop him from altering and quite possibly completely destroying the future. As she battles to stop Worth, stay hidden from her past-self, and avoid taking any action that might change the events of history, Magnus must also figure out how to get back to her own present day timeline.

Magnus flies to a remote island in Africa to meet with the Sanctuary's new top secret advisor, but lands herself in the middle of a deadly hostage situation.

Will runs into unexpected trouble and personal revelations on a trip to the Liberian Sanctuary in Monorovia. Meanwhile, Magnus has her hands full when a couple of ne'er-do-well flying Abnormals recruit her help with a questionable scheme.

A mysterious abnormal attacks Abby, and Magnus and Will discover there's only one way to communicate with this unusual enemy - through music.

Magnus is approached by a notorious leader in Hollow Earth who is looking for assistance in building a new home on the surface for his insurgents, but problems arise when the world's government gets involved. Addison reactivates Will's federal commission.

With the new Abnormal Homeland now openly under threat, Henry and Tesla learn that the SCIU weaponized Tesla's work to use against Abnormals. Bigfoot and Kate investigate Caleb's rise to power while Will and Abby look into Magnus' past.