We are introduced to the four main characters Pu, Ngoh, Duean, and Pam and their different family backgrounds. Pu lives in Kanchanaburi and wants to move to Bangkok to live with her mother while Ngoh's family just moved to a different part of Bangkok to open a new shop. Duean and Pam live in the poorer neighborhoods within Bangkok where Duean's father works as a construction manager and is looking to buy a new house. Pam's father is a police officer and her mother has a gambling problem.

Pu starts smoking and becomes friends with Ngoh. Duean comes up with a way to help support her family and help pay for her father's medical bills. At Pam's house, her father chastises her mother for her gambling problem while Ngoh's father lashes out at her mother. Pu grows more and more distant with her family and develops a little crush.

Pu comforts Ngoh and Yok returns home to his disapproving father while his mother excitedly asks him how his audition went. Ngoh returns home and asks her mother where she was. Duean's landlord sees her mother at the nightclub and Pu goes out with Louis again, trying marijuana for the first time. Ngoh is disappointed with her mother's dishonesty, and Mangkood comforts her. Duean's neighbors call her mother out for being a prostitute and they get into a fight with Pam, Joe, and Duean, ending up with them going to the police station. Pu's mother stays with Lookmoo at the hospital while Wasan and Pom are at home with Pu. Pu's life is drastically upended after returning home and Duean's mother is forced to sleep with the landlord to pay off her rent. Pu goes to school and starts thinking recklessly, with Ngoh being concerned for her safety.

Ngoh doesn't return home for the night and faces punishment from her father. Pu returns home wasted, trying to confess to her mother who won't believe her. Pam's father hits her mother after she gambled away some of their possessions. Pu, Ngoh, Duean, Pam, and Yok ditch school to go to a zoo and the beach.

Pu misses school again and Ngoh goes looking for her at the arcade. Duean doesn't show up at work and goes to a different job which makes her mother suspicious. Yok prepares for his dance competition happily but his father locks him in his room, refusing to let him go. Pu, Ngoh, Duean, and Pam trespass into a closed bowling alley and are caught. Pu, Pam, and Ngoh are punished by their parents and Duean confides in Pam.

Ngoh shows up at Pu's door after being hit by her father. Pam's father finds Pam passed out in front of his house and handcuffs her to the gate. Yok's mother goes looking for him while his father is nonchalant. Pam runs away and moves in temporarily with Pu and Yok. Duean's mother starts to grow more suspicious of Duean.

Ngoh, Pam, Pu and Yok hang out at the mall. Duean vents to Pam again, telling her about her worries. Pu sleeps over at Louis's house, trying heroin for the first time. Pam's father asks Joe if he knows where she is. Duean's mother begs her not to resort to prostitution while she refuses as she wants better treatment for her father. Pu, Ngoh, Duean, Pam, Joe, and Yok go on a trip to the beach, with Pu letting them try heroin.

The police start to become suspicious of Louis and investigate him. They try to crack down the growing heroin business, which is supplied by Louis. Pu, Pam, Duean, Ngoh, Joe, and Yok start to develop a heroin addiction. Pu steals Duean's money to get more drugs and Duean gets angry at her. Pam and Joe follow Duean to her job and Joe tells Pam a secret.

The main characters reach the peak of their heroin addiction and really attempt to stop.

The story wraps up as the four girls slowly wean off drugs and struggle with drug withdrawal.