After finding the medical file on the patient who died because of a mistake, Andrea tries to reconstruct what happened before the shooting that wiped out his memory. Marco, who was responsible for this death, and Agnese are uncooperative. Alba and Riccardo struggle to rebuild their relationship and things also get complicated between Gabriel and Elisa.

The arrival of Elisa's older sister in the hospital, a likeable, charming actress, inexplicably makes the young trainee even more surly and bad-tempered. Andrea continues to delve into the years that amnesia has wiped out, while Agnese cannot mask her jealousy over the growing rapport between Giulia and Andrea.

Lorenzo has issues again with his ex-girlfriend Chiara, who is then hospitalized after overdosing. Marco and his wife feel increasingly threatened by the research that Andrea is carrying out on Satonal, the experimental drug that appears to have caused several deaths. Meanwhile, Gabriel has to explain to his community that he intends to settle in Italy.

Andrea finds himself in hot water when a former trainee accuses him of falsifying data from a pharmaceutical trial: unable to defend himself due to his amnesia, he seeks confirmation from people close to him. In the meantime, Lorenzo has to fight to get Chiara on the transplant list and Agnese has a sudden illness.

Agnese's condition rapidly deteriorates and Andrea receives the support of the whole ward in the attempt to discover what disease she is suffering from. However, the accusations levelled against him regarding his involvement in the falsification of data on pharmaceutical trials risk him having to leave the hospital for good.